Anesthetic Effectiveness of Lidocaine Versus Articaine in Dentistry

Universidad Austral de Chile

Status and phase

Not yet enrolling

Phase 4

Conditions

Dental Pain

Treatments

Drug: lidocaine + epinephrine 1:100,000

Drug: Articaine 4% with epinephrine 1:100,000

Study type

Interventional

Funder types

Other

Identifiers

NCT07231614

ArtiVsLido

Details and patient eligibility

About

Context: Lidocaine and articaine are two of the most commonly used local anesthetics in dentistry. Lidocaine has often been the anesthetic of choice in clinical practice, but in clinical experience, articaine has proven to be more effective in controlling pain during dental procedures. (Camps-Font, O. et al. 2020).

There are still unanswered questions, such as which of the two local anesthetics is more effective in reducing pain? This could lead us to discuss which one to choose to reduce costs in the dental office.

Objective: The objective of this project is to determine and compare the effectiveness of lidocaine and articaine in clinical contexts such as tooth extraction with infiltrative techniques, seeking to provide answers that will optimize the choice of anesthetic based on the patient and the procedure, thus improving pain management and reducing costs in the dental office.

Design: Randomized double-blind experimental study, parallel groups. The control group received 2% lidocaine, and the experimental group received 4% articaine. The study will be conducted in accordance with the guidelines of the Consolidated Standards of Reporting Trials (CONSORT 2010). The probabilistic sampling technique is through simple randomization. The 100 patients who meet the inclusion criteria will be randomly assigned to the control and experimental groups in a 1:1 ratio.

Expected results: articaine shows a lower percentage of extractions with anesthetic reinforcement and, therefore, a lower average number of additional tubes.

Enrollment

100 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patients with clinical indications for simple extraction of upper and lower teeth using infiltrative anesthetic techniques.
Patients without systemic diseases (ASA I)
Patients with controlled systemic disease (ASA II)
Patients with no history of hypersensitivity to anesthetics or their components (epinephrine)
Patients with stable periodontal condition, without active infection that could affect the diffusion of the anesthetic.
Patients with the ability to understand the procedure and provide informed consent.

Exclusion criteria

Patients with uncontrolled systemic diseases ASA III and pregnant patients.
Patients requiring trunk techniques (Gow gates, Spix, Carrea)
Patients taking medication that affects the anesthetic response (tricyclic antidepressants, anticoagulants)
Patients with a history of neurological or psychiatric disorders that may influence the perception of pain or anxiety.
Patients with anatomical abnormalities in the orofacial region that interfere with the administration or action of anesthesia.
Patients with a history of recent substance abuse.