Anesthetic Efficacy in Irreversible Pulpitis

University of Sao Paulo

Status and phase: Completed; Phase 4

Conditions: Anesthesia

Treatments: Drug: Intervention: inferior alveolar nerve block injection

Study type: Interventional

Funder types: Other

Identifiers

NCT02054767

FDAAA

Details and patient eligibility

About

The purpose of this study was to compare the anesthetic efficacy of articaine, lidocaine and mepivacaine in patients with irreversible pulpitis of mandibular molar.

Full description

Conventional inferior alveolar nerve block (IANB) is the most commonly used technique for achieving pulpal anesthesia in posterior mandibular endodontic procedures. However, IANB has a high failure rate and success rates are even lower when applied for the treatment of mandibular posterior teeth with irreversible pulpitis.

Enrollment: 66 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• clinical diagnosis of irreversible pulpitis
• good health
• had at least 1 adjacent tooth plus a healthy canine

Exclusion criteria

• took medication could be interacting with any of the anesthetics used

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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66 participants in 3 patient groups

lidocaine

Experimental group

Description:

injections of 3.6 mL of 2% lidocaine with 1:100,000 epinephrine Intervention: inferior alveolar nerve block injection

Treatment:

Drug: Intervention: inferior alveolar nerve block injection

mepivacaine

Experimental group

Description:

injections of 3.6 mL of 2% mepivacaine with 1:100,000 epinephrine Intervention: inferior alveolar nerve block injection

Treatment:

Drug: Intervention: inferior alveolar nerve block injection

articaine

Experimental group

Description:

injections of 3.6 mL of 4% articaine with 1:100,000 epinephrine Intervention: inferior alveolar nerve block injection

Treatment:

Drug: Intervention: inferior alveolar nerve block injection