Anesthetic Efficacy of 2% Mepivacaine Versus 4% Articaine (Anesthesia)

Cairo University (CU)

Status and phase: Unknown; Phase 3; Phase 2

Conditions: Symptomatic Irreversible Pulpitis

Treatments: Drug: mepivicane hydrochloride; Drug: articane hydrochloride

Study type: Interventional

Funder types: Other

Identifiers

NCT03725579

CEBD-CU-2014-06-01

Details and patient eligibility

About

The aim of this prospective randomized clinical trial was compare between 2% Mepivacaine and 4% Articaine for inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis in mandibular molars as regards to their anesthetic efficiency; during access cavity preparation and instrumentation.

Full description

Sixty-six patients diagnosed clinically and radiographically with symptomatic irreversible pulpitis in mandibular posterior teeth will received single-visit root canal treatment using ProTaper Universal rotary system for canal preparation, then they will be randomly divided into two groups (n=33) according to the anesthetic solution used, either Group M (3.6 ml Mepivacaine hydrochloride 2% with 1:100000 epinephrine) or Group A (3.4 ml Articaine hydrochloride 4% with 1:100000 epinephrine). The pain will be assessed using numerical rating scale (NRS) during access cavity preparation and instrumentation, then the need for supplemental anesthesia will be also recorded.

Enrollment: 66 estimated patients

Sex: All

Ages: 20 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients in good health (American Society of Anesthesiologists Class II or higher)
2. Patients having symptomatic irreversible pulpitis in one of their mandibular molars.
3. Age range is between 20 and 50 years.
4. Patients who can understand Visual Analogue Scales VAS.
5. Patients able to sign informed consent

Exclusion criteria

1. Patients allergic to articaine and/or mepivacaine and/or sulfur
2. Patients having active sites of pathosis in the area of injection.
3. Patients having active pain in more than one molar.
4. Patients who had taken analgesics in the 12 hours preceding the injection.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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66 participants in 2 patient groups

mepivacaine hydrochloride

Experimental group

Description:

2% Mepivacaine hydrochloride with 1:100,000 epinephrine anaesthetic solution. Each patient received two inferior alveolar nerve block injections of the tested anesthetic solution by using a side loading aspirating syringe and 27-gauge long needle

Treatment:

Drug: articane hydrochloride

Drug: mepivicane hydrochloride

articaine hydrochloride

Active Comparator group

Description:

4 % Articaine hydrochloride with 1:100,000 epinephrine anaesthetic solution. Each patient received two inferior alveolar nerve block injections of the tested anesthetic solution by using a side loading aspirating syringe and 27-gauge long needle

Treatment:

Drug: articane hydrochloride

Drug: mepivicane hydrochloride