Angiogenesis Markers in Primiparas Versus Multiparas: Relevance to Preeclampsia Incidence

Hadassah Medical Center

Status: Unknown

Conditions: Pre-Eclampsia

Study type: Observational

Funder types: Other

Identifiers

NCT00262093

PRIMIMULTI-HMO-CTIL

Details and patient eligibility

About

The reason for having a higher incidence of preeclampsia in primiparas may involve angiogenesis imbalance in these patients.

Full description

Primiparity is one of the main risk factors for having preeclampsia during pregnancy. Recently, sFlt-1, soluble FMS-like tyrosine kinase-1, has been shown to be a major molecule involved in the pathogenesis of preeclampsia. Higher sFlt-1 mRNA, higher serum levels of sFlt-1 as well as lower PlGF, placental growth factor, have been found in preeclamptic patients.

We intend to check the angiogenesis profile of primiparas as compared to multiparas.

Enrollment: 200 estimated patients

Sex: Female

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Every delivery

Exclusion criteria

• Preeclampsia or pregnancy induced hypertension