Angiogenesis With Positron Emission Tomography (PET) Tracer Uptake (angiogenesis)

Gunma University

Status: Completed

Conditions: Angiogenesis; Non-Small Cell Lung Cancer

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT00671242

kkaira1970

Details and patient eligibility

About

Purpose: L-[3-18F]-α-methyltyrosine (18F-FMT) is an amino-acid tracer for PET. We have conducted a clinicopathologic study to elucidate the correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in the patients with non-small cell lung cancer (NSCLC).

Method: Thirty-seven NSCLC patients were enrolled in this study, and a pair of PET study with 18F-FMT and 18F-FDG was performed. Uptake of PET tracers was evaluated with standardized uptake value. VEGF, CD31, CD34, LAT1 and Ki-67 labeling index of the resected tumors were analyzed by immunohistochemical staining, and correlated with the clinicopathologic variables and the uptake of PET tracers.

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who underwent a thoracotomy within 4 weeks after 18F-FMT PET and 18F-FDG PET study
• Histology is non-small cell lung cancer

Exclusion criteria

• Patient who received neoadjuvant chemotherapy or radiotherapy before surgery
• Patients who have insulin-dependent diabetes

Trial design

0 participants in 2 patient groups

I

Description:

L-\[3-18F\]-α-methyltyrosine (18F-FMT) is an amino-acid tracer for PET. We have conducted a clinicopathologic study to elucidate the correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in the patients with non-small cell lung cancer

Nuclear