Angiography Derived Index of Microcirculatory Resistance in Patients With Acute Myocardial Infarction

Zhejiang University

Status: Completed

Conditions: Acute Myocardial Infarction (AMI)

Treatments: Other: Angiography derived index of micro-circulatory resistance (Angio-IMR)

Study type: Observational

Funder types: Other

Identifiers

NCT05696379

2022-0878

Details and patient eligibility

About

Coronary microcirculatory dysfunction has been known to be prevalent even after successful revascularization of acute myocardial infarction (AMI) patients, and has been shown to be associated with poor prognosis. Angiography derived index of micro-circulatory resistance (Angio-IMR) is a novel pressure-wire free approach to assess coronary microvascular disease with great diagnostic performance. The current study will further investigate the prognostic value of Angio-IMR in patients with AMI in multicenter retrospective cohort.

Enrollment: 5,000 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Acute myocardial infarction patients who underwent successful percutaneous coronary intervention

Exclusion criteria

• No appropriate coronary angiography images (inferior image quality, image loss, severe arteries overlap, or significant artifact)
• Previous coronary artery bypass graft

Trial design

5,000 participants in 4 patient groups

STEMI with high Angio-IMR

Description:

Patients with ST segment elevation myocardial infarction and high Angio-IMR

Treatment:

Other: Angiography derived index of micro-circulatory resistance (Angio-IMR)

STEMI with low Angio-IMR

Description:

Patients with ST segment elevation myocardial infarction and low Angio-IMR

Treatment:

Other: Angiography derived index of micro-circulatory resistance (Angio-IMR)

NSTEMI with high Angio-IMR

Description:

Patients with non-ST segment elevation myocardial infarction and high Angio-IMR

Treatment:

Other: Angiography derived index of micro-circulatory resistance (Angio-IMR)

NSTEMI with low Angio-IMR

Description:

Patients with non-ST segment elevation myocardial infarction and low Angio-IMR

Treatment:

Other: Angiography derived index of micro-circulatory resistance (Angio-IMR)