Angiotensin Converting Enzyme Inhibitors in Marfan Syndrome

Bayside Health

Status and phase: Completed; Phase 3

Conditions: Marfan Syndrome

Treatments: Drug: Coversyl (perindopril)

Study type: Interventional

Funder types: Other

Identifiers

NCT00485368

3/03

Details and patient eligibility

About

The purpose of this research is to assess the effects of a drug called perindopril on the aorta in people known to have Marfan Syndrome. The aorta is the major artery of the body that comes out of the heart and supplies blood to the body. We know that in people with Marfan Syndrome, the aorta is stiff and this stiffness results in its enlargement over many years. This enlargement of the aorta can be very serious. We know from treatment of other heart conditions that drugs of the same type as perindopril reduce stiffness of the arteries. This type of drug has never been tried in people with Marfan Syndrome.

Enrollment: 17 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-40
• Diagnosis of Marfan Syndrome, on the basis of the Ghent Criteria

Exclusion criteria

• Age <18, >40
• Women of child-bearing potential not on adequate contraception
• Serum creatinine of >0.11
• A history of intolerance to ACEI
• Patients on angiotensin receptor blockers
• Blood pressure >140/90mmHg
• History of previous aortic surgery

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind