Angiotensin-Converting Enzyme Polymorphism and Acute Renal Failure (ECAREA)

Caen University Hospital

Status: Terminated

Conditions: Critical Illness; Kidney Failure, Acute

Treatments: Procedure: Blood sampling for PCR

Study type: Observational

Funder types: Other

Identifiers

NCT00316576

05-130

Details and patient eligibility

About

Associations between angiotensin-converting enzyme gene polymorphism and occurrence and outcome of ARDS, and with respiratory complications post cardiopulmonary bypass have already been demonstrated. Based on physiological effects of angiotensin II, we hypothesized that the I allele of the angiotensin-converting enzyme Insertion/Deletion polymorphism may be associated with a higher risk of acute renal failure in critically ill patients.

Full description

Associations between angiotensin-converting enzyme gene polymorphism and occurrence and outcome of ARDS, and with respiratory complications post cardiopulmonary bypass have already been demonstrated. Based on physiological effects of angiotensin II, we hypothesized that the I allele of the angiotensin-converting enzyme Insertion/Deletion polymorphism may be associated with a higher risk of acute renal failure in critically ill patients.

Enrollment: 160 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 yrs
• ICU stay > 48 hours

Exclusion criteria

• Age < 18 yrs
• Creatinine > 180 µmol/L
• Absence of consent