Angiotensin II Pathway and Postoperative Hypoxemia

Capital Medical University

Status: Completed

Conditions: Aortic Dissection

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT05055570

2021107X

Details and patient eligibility

About

Acute type A aortic dissection is often accompanied by postoperative hypoxemia, the cause of which is not fully understood. Angiotensin II is an important component of the renin-angiotensin system (RAS), which has been suggested to be involved in the development of aortic dissection and pulmonary inflammation.The purpose of this study was to investigate the role and mechanism of angiotensin II pathway in postoperative hypoxemia after acute type A aortic dissection, and to provide reference for clinical application

Enrollment: 88 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing surgery for acute type A aortic dissection
• age between 18 to 80

Exclusion criteria

• perioperative severe cardiac insufficiency
• rejection of consent

Trial design

88 participants in 2 patient groups

Hypoxemia group

Description:

oxygenation index (OI)≤200

Treatment:

Other: No intervention

Non-hypoxemia group

Description:

oxygenation index (OI)\>200

Treatment:

Other: No intervention