Annexin Imaging in Dissection of the Descending Aorta (PAIDDA)

Assistance Publique - Hôpitaux de Paris

Status and phase

Not yet enrolling

Phase 2

Conditions

Chronic Dissection of Thoracic Aorta (Disorder)

Treatments

Drug: Annexin

Study type

Interventional

Funder types

Other

Identifiers

NCT03832582

P1700905J

Details and patient eligibility

About

The relationship between the presence of a partial thrombus and aortic dilation after type B dissection has recently been reported. The originality lies in the idea of imaging thrombus activity to predict dilation after type B dissection. The innovative character is based on the use of annexin scintigraphy.

Full description

To establish the proof of concept in humans of the link between the intensity of 99mTc-annexin V-128 binding in the descending thoracic aorta and the progression of aortic diameter in patients with type B aortic dissection.

Enrollment

83 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patient whose age is ≥ 18 years old
any patient seen more than 6 months and less than 5 years after a dissection involving the descending aorta at Bichat Hospital, whether it is a dissection of the descending aorta alone or a dissection of the ascending aorta extended to the descending aorta
dissection of the uncomplicated descending thoracic aorta: not requiring surgery or stent implantation within the first 6 months after acute dissection
effective contraception for women of childbearing age

Exclusion criteria

scheduled procedure for dissection of the descending aorta
contraindication to aortic CT with injection of contrast media: renal failure with creatinine clearance <30 ml/min or creatinine >200 µmol/l; allergy to contrast media
history of surgery or stent implantation in the descending thoracic aorta
pregnant or breastfeeding women
patient under guardianship or trusteeship
non affiliation to social security or CMU (beneficiary or assignee)
patient refusal to participate in the study