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Annexin Levels of Periodontal Inflammatory Regulation

M

Medipol University

Status

Completed

Conditions

Inflammation
Periodontal Diseases

Treatments

Other: Saliva, serum and GCF sampling

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

ANXA1, a member of the annexin family, plays a role in the resolution of inflammation and the regulation of anti-inflammatory responses, while ANXA2 is involved in the initiation of the inflammatory responses. The aim of this study was to determine the effects of annexin family (ANXA1 and ANXA2) in periodontal disease.

Full description

Healthy participants (n:25) and stage III, grade B periodontitis (n:25) patients enrolled for this study. Clinical periodontal parameters and PISA levels were noted. Serum, saliva, and GCF samples were collected to measure the ANXA1, ANXA2 and IL-1β levels.

Enrollment

50 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

systemically healthy

  • clinical diagnosis of periodontitis
  • clinical diagnosis of periodontal health

Exclusion criteria

  • • history of regular use of systemic antibiotics anti-inflammatory, or antioxidant drugs (previous 3 months)

    • nonsurgical periodontal treatment (previous 6 months)
    • surgical periodontal treatment (previous 12 months)
    • presence of<10 teeth
    • current medications affecting gingival health (calcium channel blockers, phenytoin, cyclosporine, and hormone replacement therapy)
    • diabetes
    • diagnosis of rheumatoid arthritis
    • pregnancy
    • lactating
    • smoking
    • excessive alcohol consumption.

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Single Group Assignment

Masking

None (Open label)

50 participants in 2 patient groups

Active Comparator
Other group
Description:
Saliva, serum and GCF collection of patients and samples molecules analysis
Treatment:
Other: Saliva, serum and GCF sampling
Experimental
Experimental group
Description:
Salivary, serum and GCF ANXA1, ANXA2 and IL-1beta observation Saliva, serum and GCF samples obtained for each patient were used for cytokine analysis. Prepared samples were analyzed for ANXA1, ANXA2 and IL-1beta using commercial ELISA kits (Elabscience, Houston, Texas, USA and Bioaasay Technology Laboratory (BT-Lab), Shanghai, China, respectively) according to the manufacturer's instructions.
Treatment:
Other: Saliva, serum and GCF sampling

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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