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ANXA1, a member of the annexin family, plays a role in the resolution of inflammation and the regulation of anti-inflammatory responses, while ANXA2 is involved in the initiation of the inflammatory responses. The aim of this study was to determine the effects of annexin family (ANXA1 and ANXA2) in periodontal disease.
Full description
Healthy participants (n:25) and stage III, grade B periodontitis (n:25) patients enrolled for this study. Clinical periodontal parameters and PISA levels were noted. Serum, saliva, and GCF samples were collected to measure the ANXA1, ANXA2 and IL-1β levels.
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Inclusion criteria
systemically healthy
Exclusion criteria
• history of regular use of systemic antibiotics anti-inflammatory, or antioxidant drugs (previous 3 months)
Primary purpose
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Interventional model
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50 participants in 2 patient groups
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Data sourced from clinicaltrials.gov
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