Anomia Therapy and Executive Function Training in Chronic Post-stroke Aphasia: Pilot Study of Multidimensional Effects (ATAC2PILOT)

University Hospital Center (CHU)

Status: Not yet enrolling

Conditions: Speech Therapy; Aphasia, Acquired

Treatments: Behavioral: Executive function training: computerized equipment; Behavioral: Anomia therapy: semantic feature analysis and phonological components analysis;

Study type: Interventional

Funder types: Other

Identifiers

NCT06712225

RECHMPL22_0566

Details and patient eligibility

About

The goal of this clinical trial is to measure the effects of a speech therapy protocol combining anomia therapy and executive function training on naming and discourse in people with chronic aphasia, and to study the related brain changes.

The main questions it aims to answer are:

• Does the protocol improve naming skills ?
• Do the improvements observed transfer to discourse abilities ?
• Are there any brain changes induced by this protocol ?

Researchers will compare anomia therapy alone to anomia therapy + executive function training to see if the latter works better.

Participants will:

• Have a whole language assessment and a Magnetic Resonance Imaging (MRI) scan in the hospital before and after the protocol
• Receive 18 sessions of the protocol, 3 times a week during 6 weeks, in the hospital
• Have several naming assessments during the protocol

Enrollment: 8 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult (18-80 years old) with post-stroke aphasia (> 6 months post-stroke)
• Participant or legal representative able to understand the aims of the study
• Participant or legal representative who have signed an informed consent form

Exclusion criteria

• Aphasia with severe anarthria (mutism), comprehension disorders or alexia, incompatible with the purpose of the study
• Contraindications for MRI
• History of head trauma, brain tumor, neurodegenerative disease, or any other neurological or psychiatric condition
• Non-affiliation to social welfare

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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8 participants in 2 patient groups

Arm A: Anomia Therapy alone

Active Comparator group

Treatment:

Behavioral: Anomia therapy: semantic feature analysis and phonological components analysis;

Arm B: Anomia Therapy + Executive Function Training

Experimental group

Treatment:

Behavioral: Anomia therapy: semantic feature analysis and phonological components analysis;

Behavioral: Executive function training: computerized equipment