Anorexia Nervosa and Brain in Adolescence

Kuopio University Hospital

Status

Not yet enrolling

Conditions

Anorexia Nervosa

Treatments

Other: Observational study methods

Study type

Observational

Funder types

Other

Identifiers

NCT06380257

ANBA

Details and patient eligibility

About

Aims of this follow-up study are to investigate effects of anorexia nervosa on brain structure and functions in adolescence.

Full description

Anorexia nervosa is severe mental health problem with increased incidence rates in adolescence. Etiology of anorexia nervosa is still mostly unkonwn. Adolescence is also critical period of brain development.

Aims of this follow-up study are to investigate effects of anorexia nervosa on brain structure and functions in both acute and remission state of anorexia nervosa in adolescence.

Study group are young anorexia nervosa patients, and control group are healthy same-aged students.

Research methods include non-invasive brain imaging methods such as Transcranial Magnetic Stimulation (TMS), and Magnetic Resonance Imaging (MRI). Other research methods are assessment of body composition, laboratory tests, self-rated questionnaires and psychiatric interview.

Enrollment

50 estimated patients

Sex

All

Ages

16 to 19 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Study group: 1) age 16-19 years, 2) BMI below 17.5, 3) diagnosis: anorexia nervosa or atypical anorexia nervosa 4) diagnosed within last two years. Inclusion criteria.

Control group : 1) age 16-19 years, 2) BMI over 19.0, 3) No lifetime obesity (BMI over 30) nor eating disorder.

Exclusion criteria

glucose metabolism disorder or any chronic medical disorder, or medicine with possible effects on neurotransmitters, 2) previous mental health problem (excluded anorexia nervosa or atypical anorexia nervosa in study group), 3) smoking, nicotine products, alcohol or any other substance abuse or dependence, 4) contraindication for used brain imaging method.