Anterior vs. Posterior Quadratus Lumborum Block in Nephrectomy Patients

Sherif Mahmoud Mohammed Bekhet

Status and phase: Unknown; Early Phase 1

Conditions: Quadratus Lumborum Block

Treatments: Procedure: Quadratus Lumborum block

Study type: Interventional

Funder types: Other

Identifiers

NCT03973398

QLB in Nephrectomy

Details and patient eligibility

About

• Primary outcome: to compare the efficacy of Anterior subcostal versus Posterior approach in ultrasound guided Quadratus Lumborum Block.
• Secondary outcome: to evaluate the efficacy of Quadratus Lumborum Block in the control of postoperative pain in patients undergoing Nephrectomy surgery, hemodynamics, any complications and patients' satisfaction..

Full description

A variant of the ultrasound-guided transversus abdominis plane (TAP) block was first described in an abstract, in which local anesthetic injection occurs at the point where the internal oblique and transversus abdominis muscles taper off and adjoin the lateral border of quadratus lumborum (QL) muscle.

Currently, the QL block is performed as one of the perioperative pain management procedures for all generations (pediatrics, pregnant, and adult) undergoing abdominal surgery.

However, there is large disagreement regarding the best approach for administering the block because of unclear mechanisms responsible for the effects and complicated nomenclature system. Nephrectomy for patients with renal cell carcinoma (RCC) was first described in 1969. Surgical treatment varies with the pathology. Simple nephrectomy is the preferred option for those with non-neoplastic disease (e.g. trauma, non-functioning kidney with chronic infection) with radical nephrectomy being preferred in those with neoplastic disease. Radical nephrectomy implies resection of the whole of Gerota's fascia, including the perinephric fat, lymphatics, and the ipsilateral adrenal gland. Here the investigators are going to compare the Anterior (subcostal) approach to the Posterior approach to determine their level of spread and their value in controlling postoperative pain in patients scheduled for Nephrectomy surgery.

Enrollment: 120 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Both sex
• Age: 18-60 years.
• ASA I and II
• Elective surgery

Exclusion criteria

• Patient's refusal.
• Allergy to local anesthetics.
• Peripheral neuropathy.
• Bleeding diathesis.
• Inflammation or infection over injection site.
• Morbid obesity.
• Patients on previous opioid therapy.
• Psychiatric disorders.
• Emergency surgery

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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120 participants in 4 patient groups, including a placebo group

Quadratus Lumborum Block anterior subcostal (QLa)

Active Comparator group

Description:

Patients in this group will receive Anterior subcostal Quadratus Lumborum block postoperative with 30 ml of 0.125 bupivacaine.

Treatment:

Procedure: Quadratus Lumborum block

Quadratus Lumborum Block posterior (QLp)

Active Comparator group

Description:

Patients in this group will receive Posterior Quadratus Lumborum block postoperative with 30 ml of 0.125 bupivacaine.

Treatment:

Procedure: Quadratus Lumborum block

Quadratus Lumborum Block anterior subcostal control (QLca)

Placebo Comparator group

Description:

Patients in this group will receive Anterior subcostal Quadratus Lumborum block postoperative with 30 ml of 0.9% normal saline.

Treatment:

Procedure: Quadratus Lumborum block

Quadratus Lumborum Block posterior control (QLcp)

Placebo Comparator group

Description:

Patients in this group will receive Anterior subcostal Quadratus Lumborum block postoperative with 30 ml of 0.9% normal saline.

Treatment:

Procedure: Quadratus Lumborum block