Anthropometric And Body Composition Measurements Related To Osteoporosis In Geriatric Population

Istanbul Medeniyet University

Status

Completed

Conditions

Obesity, Visceral

Osteoporosis Senile

Treatments

Diagnostic Test: waist circumference

Diagnostic Test: Skeletal muscle index

Diagnostic Test: Body mass index

Diagnostic Test: height

Diagnostic Test: Dual energy x ray absorptiometry (DXA)

Diagnostic Test: Fat percentage

Diagnostic Test: The Rapid Assessment of Physical Activity (RAPA) aerobic assessment

Diagnostic Test: A body shape index (ABSI)

Diagnostic Test: hip circumference

Study type

Interventional

Funder types

Other

Identifiers

NCT04255173

IMU OP

Details and patient eligibility

About

The patients who consulted to the geriatric outpatient clinic between 2018 and 2019 were included in the study. The inclusion criterions were being at or over the age of 65 and diagnosed with osteoporosis according to WHO criteria. Exclusion criteria include vertebral fracture due to known accidental traumas, history of drug therapy in the past year (biphosphonate, estrogen replacement therapy, glucocorticoids ), history of co-morbidities as malignancy, radiotherapy or chemotherapy, renal failure, hyperthyroidism, primer hyperparathyroidism, rheumatic disease or adrenal diseases.

Initially, a demographic form including age, sex, comorbidities, weight, height was filled by the participants. Body mass index (BMI, ratio of height and weight, expressed as kg/m2) calculated. Patients waist and hip circumference was measured (cm).

Fat percentage and skeletal muscle mass (SMM) was calculated by using bioimpedance analysis (BIA) (Tanita TBF 300; Tanita Corp., Tokyo, Japan). Skeletal muscle index (SMI) was calculated from BIA-based skeletal muscle mass with a formula as SMM/height [m2] [8]. ABSI is measured as waist circumference (m) / (BMI(kg)2/3x Height(m)5/6) [4].

Osteoporosis was evaluated by using dual energy x-ray absorptiometry (DXA). According to the T-scores calculated from femur neck (FN) and lumbar spine (LS), subjects divided into 3 groups as following: a) normal: T-score is greater than -1 SD, b) osteopenia: T-score is between -1 and -2.5 SD, c) osteoporosis: T-score is lower than -2.5 SD.

Physical activity levels of patients were evaluated with The Rapid Assessment of Physical Activity (RAPA) aerobic assessment [9]. Patients divided into 5 groups as following: 1 = sedentary, 2 = underactive, 3 = regular underactive (light activities), 4 = regular underactive, and 5 = regular active).

The study protocol was approved by the ethics committee (2018/0478) and all participants gave written informed consent.

Enrollment

571 patients

Sex

All

Ages

65+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

being at or over the age of 65
diagnosed with osteoporosis according to WHO criteria

Exclusion criteria

vertebral fracture due to known accidental traumas
history of drug therapy in the past year (biphosphonate, estrogen replacement therapy, glucocorticoids )
history of co-morbidities as malignancy, radiotherapy or chemotherapy, renal failure, hyperthyroidism, primer hyperparathyroidism, rheumatic disease or adrenal diseases

Trial design

Primary purpose

Diagnostic

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

571 participants in 1 patient group

Geriatric osteoporotic patients

Experimental group

Description:

We measured different anthropometric and body composition measurements as body weight, BMI, percentage body fat, skeletal muscle index (SMI), ABSI, waist (WC) and hip circumference (HC) in geriatric population to investigate the relation to osteoporosis.

Treatment: