Anti COVID-19 Antibodies in Follicular Fluid and Spermatic Fluid

Clalit Health Services

Status: Unknown

Conditions: SARS-CoV-2

Treatments: Diagnostic Test: Anti COVID19 IgG Antibodies

Study type: Observational

Funder types: Other

Identifiers

NCT04822012

0053-21-HMO

Details and patient eligibility

About

Patients going through an in vitro fertilization cycle will be asked to participate . Patients will be asked for their COVID-19 exposure : post confirmed disease/post vaccine/not exposed to disease or vaccine . Patients will provide the fluids which are not required , once fertilization process is completed. Patients will also provide 5ml blood sample by the day of procedure. Anti COVID-19 immunoglobulin G type antibodies will be measured in all samples . Data regarding age, date of infection/vaccine will be collected . Progesterone and Estrogen will be measured in female patients' samples and Perlecan level will be measured in follicular fluid.

Full description

Patients going through an in vitro fertilization cycle will be asked to participate . Patients will be asked for their COVID-19 exposure : post confirmed disease/post vaccine/not exposed to disease or vaccine . Patients will provide the fluids which are not required in the day of egg retrieval : the follicular fluid remaining after isolation of the egg and spermatic fluid only, if not utilized for fertilization. The fluids will be collected once fertilization process is completed. Patients will also provide 5ml blood sample by the day of procedure. Anti COVID-19 immunoglobulin G type antibodies will be measured in all samples . Data regarding age, date of infection/vaccine will be collected as well as indication for treatment, Estradiol level before the egg retrieval, number of eggs collected and the triggering ovulation modality . Progesterone and Estrogen will be measured in female patients' samples (follicular fluid and serum). Perlecan level will be measured in follicular fluid.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Planned egg retrieval procedure (including egg preservation)
• Negative PCR for SARS-Cov-19 in the week before egg retrival
• Informed consent

Exclusion criteria

• Positive PCR for SARS-Cov-19 in the week before egg retrival
• expected retrival of 1-3 eggs

Trial design

50 participants in 2 patient groups

Female

Description:

Female patients going through an egg retrival procedure and were identified as post COVID-19 vaccine/ post COVIS-19 infection or not post vaccine/post disease and screened negative for COVID-19 in the week prior to the procedure.

Treatment:

Diagnostic Test: Anti COVID19 IgG Antibodies

Male

Description:

male patients going through an in vitro fertilization cycle and were identified as post COVID-19 vaccine/ post COVIS-19 infection or not post vaccine/post disease and screened negative for COVID-19 in the week prior to the procedure.

Treatment:

Diagnostic Test: Anti COVID19 IgG Antibodies