Anti-diabetic Effects of Persimmon Leaf Extract

Chonbuk National University

Status: Completed

Conditions: Prediabetes

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Persimmon leaf extract

Study type: Interventional

Funder types: Other

Identifiers

NCT02706821

WJG-HG-PLE

Details and patient eligibility

About

The investigators performed a 8-week, randomized, double-blind, placebo-controlled crossover human trial to evaluate the efficacy and safety of persimmon leaf extract on blood glucose. The investigators measures changes in diabetes associated parameters, including fasting blood glucose, postprandial blood glucose, insulin, C-peptide and HbA1c.

Enrollment: 34 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 20-75 years
• Fasting blood glucose (FPG) 100~140 mg/dL or postprandial blood glucose (PPG) 140~250 mg/dL

Exclusion criteria

• FPG more than 140 mg/dL
• 2h PPG more than 200 mg/dL
• Type 1 diabetes or HbA1c more than 9.0%
• treatment with corticosteroids within the past 4 weeks
• cardiovascular disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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34 participants in 2 patient groups

Treatment sequence 1

Active Comparator group

Description:

PLE (persimmon leaf extract) once a day during 8 weeks cross-over to placebo once a day during 8 weeks.

Treatment:

Dietary Supplement: Persimmon leaf extract

Dietary Supplement: Placebo

Treatment sequence 2

Active Comparator group

Description:

Placebo once a day during 8 weeks cross-over to PLE once a day during 8 weeks.

Treatment:

Dietary Supplement: Persimmon leaf extract

Dietary Supplement: Placebo