Anti-hypertensive Medication Dosing Regimen in Effective Blood Pressure Control (HARMONY)

Imperial College London

Status and phase

Completed

Phase 4

Conditions

Hypertension

Treatments

Drug: Anti-hypertensive Medication -

Study type

Interventional

Funder types

Other

Identifiers

NCT01669928

CRO1749

Details and patient eligibility

About

A randomised crossover trial of anti-hypertensive medication dosing regimen in effective blood pressure control.

To investigate whether there is a difference in 24 hour blood pressure (BP) control when antihypertensive medications are taken in the morning compared with the evening.

Full description

The identification of any significant difference could lead to more effective therapeutic management of arterial hypertension, which in turn would result in a reduced cardiovascular burden, lower costs and a better quality of life for hypertensive patients.

Enrollment

103 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Caucasian patients aged 18-80 years;
History of any grade of hypertension for at least 1 year, including at least 3 months of constant antihypertensive medication (consisting of ≥ 1 antihypertensive drugs, each administered in one dose daily), with reasonably controlled BP (≤150/90 mmHg and ≥ 115/75 mmHg on usual medication) based on previous clinic records, in the last 3 months.

Exclusion criteria

BP levels > 150/90 mmHg or < 115/75 mmHg in the last 3 months.
Postural hypotension, defined as symptoms resulting from a > 20 mm Hg drop of systolic BP or a > 10 mm Hg drop of diastolic BP or both between 1 and 3 min after standing from the sitting position.
Known Extreme dippers at baseline (fall of mean night time SBP > 20% of mean day time SBP)
Individuals with jobs which require night-time shift work.
Pregnant women or those planning to become pregnant.