Anti-inflammatory Effect of Aerobic Exercise in Individual With Increased Cardiovascular Risk

Escola Bahiana de Medicina e Saude Publica

Status and phase: Completed; Phase 2

Conditions: Inflammation

Treatments: Behavioral: Only Counseling; Behavioral: Aerobic Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT01903941

CRPExercise

Details and patient eligibility

About

Aerobic physical activity attenuates systemic inflammatory activity in individuals with cardiovascular risk.

Full description

Background: Observational studies suggest that exercise has anti-inflammatory effect, however this idea has not been definitively confirmed by randomized clinical trials.

Objective: To test the hypothesis that aerobic exercise attenuates systemic inflammatory activity in individuals with cardiovascular risk.

Methods: Randomized controlled trial, which included 68 sedentary individuals, with at least two risk factors for coronary heart disease or established cardiovascular disease. The volunteers were randomized to 3 months of supervised aerobic training or just advice when healthy lifestyles. C-reactive protein (CRP) was measured by the method of high sensitivity before and after 3 months of intervention.

Enrollment: 68 patients

Sex: All

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Individuals with are between 40 to 70 years, no regular exercise, and at least two risk factor for cardiovascular disease (diabetes, hypertension, dyslipidemia, smoking) or documented cardiovascular disease.

Exclusion criteria

• Incapacity to exercise.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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68 participants in 2 patient groups, including a placebo group

Training

Experimental group

Description:

Aerobic

Treatment:

Behavioral: Aerobic Exercise

Control

Placebo Comparator group

Description:

Not exercise

Treatment:

Behavioral: Only Counseling