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Anti-inflammatory Effect of Aerobic Exercise in Individual With Increased Cardiovascular Risk

E

Escola Bahiana de Medicina e Saude Publica

Status and phase

Completed
Phase 2

Conditions

Inflammation

Treatments

Behavioral: Only Counseling
Behavioral: Aerobic Exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT01903941
CRPExercise

Details and patient eligibility

About

Aerobic physical activity attenuates systemic inflammatory activity in individuals with cardiovascular risk.

Full description

Background: Observational studies suggest that exercise has anti-inflammatory effect, however this idea has not been definitively confirmed by randomized clinical trials.

Objective: To test the hypothesis that aerobic exercise attenuates systemic inflammatory activity in individuals with cardiovascular risk.

Methods: Randomized controlled trial, which included 68 sedentary individuals, with at least two risk factors for coronary heart disease or established cardiovascular disease. The volunteers were randomized to 3 months of supervised aerobic training or just advice when healthy lifestyles. C-reactive protein (CRP) was measured by the method of high sensitivity before and after 3 months of intervention.

Enrollment

68 patients

Sex

All

Ages

40 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Individuals with are between 40 to 70 years, no regular exercise, and at least two risk factor for cardiovascular disease (diabetes, hypertension, dyslipidemia, smoking) or documented cardiovascular disease.

Exclusion criteria

  • Incapacity to exercise.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Single Group Assignment

Masking

None (Open label)

68 participants in 2 patient groups, including a placebo group

Training
Experimental group
Description:
Aerobic
Treatment:
Behavioral: Aerobic Exercise
Control
Placebo Comparator group
Description:
Not exercise
Treatment:
Behavioral: Only Counseling

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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