Anti-inflammatory Nutrition on the Outcomes of Non-surgical Periodontal Therapy

Recep Tayyip Erdogan University Training and Research Hospital

Status

Enrolling

Conditions

Periodontitis

Treatments

Other: anti-inflammatory nutrition education

Other: non surgical periodontal trearment

Study type

Observational

Funder types

Other

Identifiers

NCT07287540

Recep TayyipErdoğan University

Details and patient eligibility

About

This study aimed to determine the effect of anti-inflammatory nutrition on non-surgical periodontal treatment in individuals with periodontitis by evaluating gingival crevicular fluid (GCF) and serum biomarkers and clinical periodontal parameters.

A total of 100 volunteers identified as having a pro-inflammatory diet (Q3 and Q4) will be included in the study. Individuals will be assigned to two groups. These groups will then be further divided into two groups based on whether or not they will receive anti-inflammatory nutrition education. Group Q3-1 (n=25) will receive non-surgical periodontal treatment and anti-inflammatory nutrition education. Group Q3-2 (n=25) will receive only non-surgical periodontal treatment. Group Q4-1 (n=25) will receive non-surgical periodontal treatment and anti-inflammatory nutrition education. Group Q4-2 (n=25) will receive only non-surgical periodontal treatment. After the periodontal index measurements are completed, the patients will receive non-surgical periodontal treatment. GCF and serum samples, periodontal clinical parameters and Dietary Inflammatory Index will be collected 3 times: at baseline, 1.5 and 3 months after non-surgical periodontal treatment. Levels of interleukin (IL)-1β, IL-10, tumor necrosis factor (TNF)-α, total oxidant status (TOS), total antioxidant status (TAS), and C-reactive protein (CRP) will be assessed from these samples. This will investigate the role of anti-inflammatory nutrition in reducing periodontal inflammation and increasing treatment success.

Enrollment

100 estimated patients

Sex

All

Ages

20 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Being systemically healthy
Not smoking
Not using anti-inflammatory drugs in the last 3 months, antibiotics, or systemic corticosteroids in the last 6 months
Not being pregnant or lactating
Not having received periodontal treatment in the last 6 months
Having at least 20 teeth in the mouth
Being diagnosed with periodontitis by the investigator
Having a dietary inflammatory index >0

Exclusion criteria

Having a systemic disease
Smoking
Using anti-inflammatory drugs within the last 3 months, antibiotics within the last 6 months, or systemic corticosteroids
Being pregnant or lactating
Having received periodontal treatment within the last 6 months
Having fewer than 20 teeth in the mouth
No periodontitis