Anti-inflammatory Therapy Following Selective Laser Trabeculoplasty

Queen's University

Status: Completed

Conditions: Primary Open Angle Glaucoma; Pseudoexfoliation Glaucoma

Treatments: Drug: Artificial Tears (Methyl cellulose drops); Drug: prednisolone 1%; Drug: ketorolac 0.5%

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00485108

DJ1

Details and patient eligibility

About

The type of anti-inflammatory medication used post selective laser trabeculoplasty (SLT) may have an impact on the intra-ocular pressure (IOP) lowering effect of SLT. This study will evaluate the IOP lowering effect of SLT following the topical administration of one of the following: prednisolone 1%, ketorolac 0.5% or artificial tears.

Full description

Patients who have been chosen to undergo SLT for glaucoma will be randomized to receive one of prednisolone 1%, ketorolac 0.5% or artificial tears four times a day for 5 days following administration of the laser treatment. The IOP will be measured at various time points following SLT: 1 hour, 2 days, 1 week, 1 month, 3 months, 6 months, and 1 year.

Enrollment: 120 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• primary open angle glaucoma, pseudo exfoliation glaucoma

Exclusion criteria

• previous incisional glaucoma surgery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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120 participants in 3 patient groups, including a placebo group

1

Active Comparator group

Description:

Prednisolone 1% eye drop

Treatment:

Drug: prednisolone 1%

2

Active Comparator group

Description:

ketorolac 0.5% eye drop

Treatment:

Drug: ketorolac 0.5%

3

Placebo Comparator group

Description:

Artificial Tears (methyl cellulose eye drop)

Treatment:

Drug: Artificial Tears (Methyl cellulose drops)