Anti-insulin-like Growth Factor-1 Receptor (IGF-1R) Antibodies in Graves' Disease and Graves' Orbitopathy (IGF1RAbsGO)

University of Pisa

Status: Completed

Conditions: Graves Ophthalmopathy; Autoimmune Thyroiditis; Graves Disease

Treatments: Diagnostic Test: Serum antibodies against the IGF-1R

Study type: Observational

Funder types: Other

Identifiers

NCT03498417

IGF1-R-Abs

Details and patient eligibility

About

The study is aimed at assessing IGF-1R-Abs in patients with Graves' disease, with or without GO, compared with healthy subjects and patients with autoimmune thyroiditis in a cross-sectional investigation.

Enrollment: 135 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. for Graves' disease: a history of hyperthyroidism, associated with previous or present detectable serum autoantibodies against the TSH-R;
2. for autoimmune thyroiditis: the presence of at least two of the following: a) primary hypothyroidism; b) detectable serum autoantibodies against thyroglobulin or thyroperoxidase ; c) a hypoechoic pattern of the thyroid by ultrasound examination.
3. for healthy subjects: absence of any clinical, biochemical or instrumental evidence of thyroid diseases.

For all subjects: Informed consent

Exclusion criteria

1. lack of informed consent

Trial design

135 participants in 3 patient groups

Graves' diseases

Description:

Patients with Graves' disease. No interventions foreseen

Treatment:

Diagnostic Test: Serum antibodies against the IGF-1R

Autoimmune thyroiditis

Description:

Patients with autoimmune thyroiditis. No interventions foreseen

Treatment:

Diagnostic Test: Serum antibodies against the IGF-1R

Healthy Subjects

Description:

Normal healthy subjects. No interventions foreseen

Treatment:

Diagnostic Test: Serum antibodies against the IGF-1R