Anti KU Antibodies and Its Relationship With Systemic Lupus Erythematosus

Sohag University

Status: Enrolling

Conditions: Systemic Lupus Erythematosus

Treatments: Diagnostic Test: Anti _KU antibodies

Study type: Interventional

Funder types: Other

Identifiers

NCT05900232

Soh-Med-23-05-05MD

Details and patient eligibility

About

systemic lupus Erythematosus (SLE) is a multi system autoimmune disorder abroad spectrum of clinical presentations.

Diagnosis of SLE depending on Systemic Lupus International Collaborating Clinics (SLICC) Criteria.

SLICC Criteria requires either that a patient satisfy at least 4 of 17 Criteria including at least 1 of 11 clinical criteria and 1 of 6 immunological criteria or the patient has biopsy -proven nephritis compatible with SLE in the presence of antinuclear antibodies (ANA)or anti_double stranded DNA (dsDNA) antibodies.

Anti_KU antibodies included in (ANA), reported in many autoimmune disorders like SLE,Sjogren syndrome, idiopathic lung fibrosis and myositis.

So the aim of the work is to determine the relationship between Anti_KU antibodies and SLE manifestations.

Enrollment: 60 estimated patients

Sex: All

Ages: 17 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• all patients will fulfill the Systemic Lupus International Clinics(SLICC) classification criteria for Systemic Lupus Erythematosus.

Exclusion criteria

• any patient with any collagen disease other than SLE

Trial design

Primary purpose: Screening

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)