Anti-oxidative Influence From Pomegranate Tablets on Male Sperm Quality in Couples Undergo Infertility Treatments Due to Male Infertility.

Hillel Yaffe Medical Center

Status and phase: Unknown; Phase 3

Conditions: Male Infertility With Severe Oligo-terato-asteno-spermia

Treatments: Dietary Supplement: Pomegranate pills

Study type: Interventional

Funder types: Other

Identifiers

NCT01918163

0059-13HYMC

Details and patient eligibility

About

Some animal studies revealed that the pomegranate juice may improve sperm quality in terms of concentration, motility and morphology, as well as in fertilization rate.

Minor data is available regarding the influence on male sperm.

Full description

Pomegranate contains a high concentration of vitamins ( C, B1, B2, B3, B5), potassium, Magnesium , Zinc and is a good source for polyphenols .Polyphenols molecules have been found to possess antioxidant properties and may effects the expression of different genes . Recent studies indicate that among foods that contain polyphenols, juice extracted from the pomegranate has the highest concentration of measurable polyphenols . Pomegranates have shown inhibitory effect on NF-κB and the MAP kinases JNK and ERK, which are critical steps in the cascade of events leading to inflammatory response. The NF- κB pathway is activated in response to bacterial infection and initiates the inflammatory cascade, which may explain the protective effect of Pomegranates on bacterial infections.

Enrollment: 55 estimated patients

Sex: Male

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• TMC of less than 5 million spermatogonia in native sperm and morphology less than 4% by Kruger criteria.

Exclusion criteria

• sensitivity to Pomegranate

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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55 participants in 2 patient groups

No Pills

No Intervention group

Description:

Patients in this group will not receive Pomegranate pills.

Pomegranate pills

Active Comparator group

Description:

The reccruited patient will receive pomegranate pills every day for 12 weeks. The control group will not be exposed for the pills.

Treatment:

Dietary Supplement: Pomegranate pills