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Anti-oxidative Influence From Pomegranate Tablets on Male Sperm Quality in Couples Undergo Infertility Treatments Due to Male Infertility.

H

Hillel Yaffe Medical Center

Status and phase

Unknown
Phase 3

Conditions

Male Infertility With Severe Oligo-terato-asteno-spermia

Treatments

Dietary Supplement: Pomegranate pills

Study type

Interventional

Funder types

Other

Identifiers

NCT01918163
0059-13HYMC

Details and patient eligibility

About

Some animal studies revealed that the pomegranate juice may improve sperm quality in terms of concentration, motility and morphology, as well as in fertilization rate.

Minor data is available regarding the influence on male sperm.

Full description

Pomegranate contains a high concentration of vitamins ( C, B1, B2, B3, B5), potassium, Magnesium , Zinc and is a good source for polyphenols .Polyphenols molecules have been found to possess antioxidant properties and may effects the expression of different genes . Recent studies indicate that among foods that contain polyphenols, juice extracted from the pomegranate has the highest concentration of measurable polyphenols . Pomegranates have shown inhibitory effect on NF-κB and the MAP kinases JNK and ERK, which are critical steps in the cascade of events leading to inflammatory response. The NF- κB pathway is activated in response to bacterial infection and initiates the inflammatory cascade, which may explain the protective effect of Pomegranates on bacterial infections.

Enrollment

55 estimated patients

Sex

Male

Ages

20 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • TMC of less than 5 million spermatogonia in native sperm and morphology less than 4% by Kruger criteria.

Exclusion criteria

  • sensitivity to Pomegranate

Trial design

Primary purpose

Supportive Care

Allocation

Randomized

Interventional model

Factorial Assignment

Masking

None (Open label)

55 participants in 2 patient groups

No Pills
No Intervention group
Description:
Patients in this group will not receive Pomegranate pills.
Pomegranate pills
Active Comparator group
Description:
The reccruited patient will receive pomegranate pills every day for 12 weeks. The control group will not be exposed for the pills.
Treatment:
Dietary Supplement: Pomegranate pills

Trial contacts and locations

1

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Central trial contact

Ellenbogen Adrian, MD; Einat Shalom-Paz, MD

Data sourced from clinicaltrials.gov

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