Anti-Proteinuric Response to ACEI, ARB and Diuretics Combination.

Nantes University Hospital (NUH)

Status and phase: Terminated; Phase 4

Conditions: Heavy Proteinuria

Treatments: Drug: ramipril 10 mg + valsartan 160 mg/day,; Drug: ramipril 5 mg + valsartan 80 mg/day + increased dosage of furosémide.; Drug: ramipril 5 mg + valsartan 80 mg/day,

Study type: Interventional

Funder types: Other

Identifiers

NCT00200694

BRD 03-5-D

Details and patient eligibility

About

Determine the best strategy for proteinuria lowering in patients with proteinuria > 1 g/day receiving ACEI and ARB combination: either increase of ACEI and ARB dosage or increase of diuretic dosage.

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• proteinuria > 1 g/day with ramipril 5 + valsartan 80 mg/day for 2 months
• proteinuria changes < 50% on 3 separate dosages over 2 months.

Exclusion criteria

• age < 18 or > 80 years systolic BP < 110 or ≥ 140 mmHg, serum creatinine > 250 mmole/L
• serum creatinine increase on ramipril + valsartan > 20%
• intolerance to ACEI or ARB