Anti-psoriatic Effect of TL01 Light Therapy

University of Aberdeen

Status

Completed

Conditions

Psoriasis

Treatments

Device: TL01 light treatment

Study type

Interventional

Funder types

Other

Identifiers

NCT02599415

2/044/14

Details and patient eligibility

About

This is a pilot study to investigate the effect of TL01 narrow band UVB therapy on the resident dermal dendritic cells characterized by expression of CD1c and CD141. These cells were reported to have a role in induction of tolerogenic regulatory T cells and production of IL-10. The investigators proposed to investigate the effect of NB-UVB on these subsets of cells after two weeks of treatment to provide better understanding of the mechanism of action of light treatment.

Full description

Six patients with plaque psoriasis were recruited from the phototherapy unit. These patients were referred by their dermatologist to receive narrow-band UVB (TL01) light treatment. Two 6 mm lesional skin punch biopsies were taken at baseline and 2 weeks after commencing the light treatment to study the effect of light on innate immune cells involved in psoriasis pathogenesis.

Enrollment

6 patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Male and female psoriasis patients in whom the decision to treat with NB-UVB therapy, as part of their routine clinical care, has been taken by their dermatologist in the age range of 18-70 years.

Exclusion criteria

patients currently on antipsoriatic treatment.
- Patients with immunosuppressive diseases
- Patients on immunosuppressive therapies
- Pregnant or lactating female patients
- Patients unable to provide a written consentProcedure