Anti-recurrence Treatment of Postresection on HCC Patients With MVI Presence and Over-expression of ASPH

Naval Military Medical University (Second Military Medical University)

Status and phase: Unknown; Phase 1

Conditions: Hepatocellular Carcinoma

Treatments: Procedure: TACE

Study type: Interventional

Funder types: Other

Identifiers

NCT02587884

EHBHKY2015-01-024

Details and patient eligibility

About

The aim of this study is to explore the effect of Transarterial Chemoembolization (TACE) on the prognosis of patients with microvascular invasion presence(MVI) and overexpression of Aspartate-β-hydroxylase(ASPH).

Enrollment: 180 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Via clinical diagnosis and confirm it is primary liver cancer
2. Pathological evidence of HCC
3. Confirm presence of MVI and over-expression of ASPH after opreation
4. Within Milan criteria
5. Estimate tumor can gain treatment of curing operation
6. No evidence for extrahepatic metestasis
7. liver function ：Child-Pugh A/B

Exclusion criteria

1. Reject to attend
2. Impossible to come to our hospital for physical examination regularly
3. Patients with apparent cardiac, pulmonary, cerebral and renal dysfunction
4. Female with pregnancy or during the lactation period

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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180 participants in 2 patient groups

Group TACE

Active Comparator group

Description:

Patients will treated with TACE after resection.

Treatment:

Procedure: TACE

Group Control

No Intervention group

Description:

Patients will treated without TACE after resection.