Anti-VEGF Instead of Intraoperative Fan-shaped Photocoagulation in BRVO Combined With Vitreous Hemorrhage

Wenzhou Medical University

Status: Unknown

Conditions: Vitrectomy; Anti-VEGF; Branch Retinal Vein Occlusion

Treatments: Procedure: anti-VEGF; Procedure: fan-shaped photocoagulation

Study type: Interventional

Funder types: Other

Identifiers

NCT03637283

10008 (Registry Identifier)

Details and patient eligibility

About

To evaluate the efficacy and safety of Anti-VEGF instead of intraoperative fan-shaped photocoagulation in BRVO combined with vitreous hemorrhage.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age ≥ 18 years old;
2. BRVO is diagnosed
3. Vitreous hemorrhage
4. Vitreous hemorrhage combined with mild retinal fibrovascular proliferation (early fibrous vascular membrane, thin fibrous vascular membrane, loose retinal adhesion and intact local retinal structure)

Exclusion criteria

1. BRVO combined with severe retinal fibrovascular proliferation (long-term fibrovascular membrane, thick fibrous vascular membrane and tightly attached to the retina, deformation of local retinal, retinal tear or suspension of retinal vein )
2. BRVO combined with retinal detachment
3. Retinal veins are completely whitened
4. iris neovascularization or neovascular glaucoma
5. Combined glaucoma
6. combined with other retinopathy
7. Received anti-VEGF treatment within 3 months before surgery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

anti-VEGF

Experimental group

Description:

vitreoretinal surgery combined with intraoperative anti-VEGF

Treatment:

Procedure: anti-VEGF

fan-shaped photocoagulation

Active Comparator group

Description:

vitreoretinal surgery combined with fan-shaped photocoagulation

Treatment:

Procedure: fan-shaped photocoagulation