Anti-VEGF Instead of Intraoperative PRP in Proliferative Diabetic Retinopathy

Wenzhou Medical University

Status: Unknown

Conditions: Vitrectomy; PRP; Proliferative Diabetic Retinopathy; Anti-VEGF

Treatments: Procedure: anti-VEGF; Procedure: PRP

Study type: Interventional

Funder types: Other

Identifiers

NCT03633266

10007

Details and patient eligibility

About

To evaluate the efficacy and safety of vitreoretinal surgery combined with anti-VEGF therapy in the replacement of intraoperative PRP in PDR therapy.

Enrollment: 220 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age≥18 years old;
2. type 1 or type 2 diabetes.
3. proliferative diabetic retinopathy with vitreous hemorrhage, and conservative treatment of vitreous hemorrhage without obvious absorption for 1 month requires vitreoretinal surgery;
4. The postoperative refractive medium is clear and the pupil is large enough to obtain sufficient clear fundus

Exclusion criteria

1. Previously received panretinal photocoagulation or unfinished panretinal photocoagulation;
2. Pulling retinal detachment involving the macula or the presence of extensive fiber proliferation requires silicone oil filling;
3. anterior chamber neovascularization or neovascular glaucoma;
4. other vascular diseases such as retinal vein occlusion, arterial occlusion, etc;
5. received intraocular anti-VEGF therapy or triamcinolone acetonide treatment which are still in the treatment period.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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220 participants in 2 patient groups

anti-VEGF

Experimental group

Description:

experimental group: vitreoretinal surgery combined with intraoperative anti-VEGF

Treatment:

Procedure: anti-VEGF

PRP

Active Comparator group

Description:

Control group: vitreoretinal surgery combined with intraoperative PRP

Treatment:

Procedure: PRP