Antiacne Medications Pseudotumor Cerebri (AAMPTC)

University of Zurich (UZH)

Status and phase: Unknown; Phase 4

Conditions: Optic Disc Swelling

Treatments: Other: Retinal nerve fibre layer measurement

Study type: Interventional

Funder types: Other

Identifiers

NCT02149615

2013DR4066 (Other Identifier)

KEK-ZH 2013-0433 AAMPTC

Details and patient eligibility

About

The exact incidence of optic disc swelling and idiopathic intracranial hypertension in patients using antiacne medication is not known so far. The investigators hypothesize that swelling of retinal nerve fibre layer measured by optical coherence tomography is more frequent then assumed so far.

Full description

Measurement of retinal nerve fibre layer using optical coherence tomography over a period of 6 to 9 months depending on exact antiacne medication.

Enrollment: 310 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Antiacne medication treatment indicated by dermatologist
• age > 18 years
• contraception if indicated

Exclusion criteria

• age < 18 years

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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310 participants in 4 patient groups

isotretinoin

Experimental group

Description:

Retinal nerve fibre layer measurement in patients under isotretinoin treatment

Treatment:

Other: Retinal nerve fibre layer measurement

lymecycline

Active Comparator group

Description:

Retinal nerve fibre layer measurement in patients under lymecycline treatment

Treatment:

Other: Retinal nerve fibre layer measurement

minocycline

Active Comparator group

Description:

Retinal nerve fibre layer measurement in patients under minocycline treatment

Treatment:

Other: Retinal nerve fibre layer measurement

doxycycline

Active Comparator group

Description:

Retinal nerve fibre layer measurement in patients under doxycycline treatment

Treatment:

Other: Retinal nerve fibre layer measurement