Antibacterial Effect of Guava Leaves Extract Mouthwash Compared to Chlorhexidine Mouthwash in High Caries Risk Patients

Cairo University (CU)

Status and phase: Unknown; Phase 3; Phase 2

Conditions: Patient Satisfaction to Taste; Salivary pH; High Caries Risk Patients; Antimicrobial Effect

Treatments: Drug: Chlorhexidine; Drug: Guava leaves extract

Study type: Interventional

Funder types: Other

Identifiers

NCT03773094

Guava leaves extract CHX

Details and patient eligibility

About

This trial is to test the antibacterial effect of Guava leaves extract mouth wash compared to Chlorhexidine mouth wash in high caries risk patients.

Also salivary pH and patient satisfaction to taste will also be tested.

Full description

This study is conducted to evaluate the effect of Guava leaves extract mouth wash on anti-bacterial activity against streptococcus mutans, salivary pH and patient satisfaction to taste compared to Chlorhexidine mouth wash.

P: Population with high caries risk patients I: Intervention by Guava leaves extract mouthwash C: Control is Chlorhexidine mouthwash O1: The primary outcome is antibacterial activity. O2: The secondary outcome is salivary pH O3: The tertiary outcome is patient satisfaction to taste

Enrollment: 94 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

1. High caries risk patients
2. 18-50 years
3. Healthy cooperative patients
4. Males or Females

Exclusion Criteria

1. Medically compromised patients
2. Patients with any systemic disease that might affect the salivary flow
3. Allergy to any of the ingredients
4. Patients with physical limitations that might affect normal tooth brushing and mouth rinsing
5. Presence of intraoral infections
6. Currently using any mouth rinse
7. Smokers
8. Use of antibiotics in the previous 30 days

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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94 participants in 2 patient groups

Guava leaves extract

Experimental group

Description:

A natural product that is prepared as a mouthwash

Treatment:

Drug: Guava leaves extract

Chlorhexidine

Active Comparator group

Description:

chemical agent Chlorhexidine as a mouthwash

Treatment:

Drug: Chlorhexidine