Antibacterial Effect of Probiotic Yogurt Compared to Xylitol

Cairo University (CU)

Status: Unknown

Conditions: Geriatric Patients

Treatments: Dietary Supplement: xylitol chewing gum; Dietary Supplement: Probiotic yogurt

Study type: Interventional

Funder types: Other

Identifiers

NCT03889015

probiotic versus xylitol

Details and patient eligibility

About

This study will be conducted to evaluate the antibacterial effect of probiotic bacteria in yogurt in decreasing streptococcus mutans count in saliva and plaque, decreasing bacterial adherence and increasing salivary pH compared to xylitol-containing chewing gum after three months.

Full description

The subjects will be assigned randomly into two equal groups to receive either probiotic yogurt or xylitol-containing chewing gum for three months. The probiotic yogurt is (Activia; Danone, Egypt) containing Bifidobacterium (7x107 CFU/g). The subjects assigned to probiotic yogurt group will be instructed to eat 100 g of the provided yogurt 10 minutes after dinner and not to brush their teeth until one hour later. The subjects assigned to the xylitol-chewing gum group will be instructed to chew the provided gum three times daily for five minutes after each meal.

Enrollment: 96 estimated patients

Sex: All

Ages: 50+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Above 50 years old.
• Have sufficient cognitive ability to understand consent procedures.
• Males or Females.
• Co-operative patients.
• High caries risk patients (≥105 CFU for streptococcus mutans count)

Exclusion criteria

• Under antibiotic treatment
• Milk intolerant
• Consuming any other probiotic product
• Habitual consumers of xylitol products
• Use antibacterial mouthwash
• Lack of compliance
• Any systemic condition affecting salivary secretion

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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96 participants in 2 patient groups

xylitol chewing gum

Active Comparator group

Description:

Xylitol is widely used as an added sweetener in sugar-free products. It has been found to prevent dental caries through reducing dental plaque and limiting salivary streptococcus mutans counts and their produced levels of lactic acid

Treatment:

Dietary Supplement: xylitol chewing gum

probiotic yogurt

Experimental group

Description:

Probiotics are live microorganisms that confer oral health benefits by adhering to the oral mucosa and surface of teeth as a part of the biofilm thus preventing the adhesion, colonization, and proliferation of cariogenic bacteria inhibiting the formation of pathogenic plaque

Treatment:

Dietary Supplement: Probiotic yogurt