Antibacterial Effectiveness of Two Root Canal Irrigants

U

University of Oslo

Status and phase

Completed
Phase 2

Conditions

Periapical Periodontitis

Treatments

Procedure: Retreatment of root-filled teeth with infection

Study type

Interventional

Funder types

Other

Identifiers

NCT02747082
2012/364/REK

Details and patient eligibility

About

The aim of this randomized clinical trial is to compare the antibacterial effects of 1% sodium hypochlorite (NaOCl) and 2% chlorhexidine gluconate (CHX) during retreatment of teeth with apical periodontitis (AP).

Full description

Root canal-treated teeth with AP were randomly distributed in two groups according to the irrigant used. After removal of the previous filling material, bacteriological samples were taken from the canals before (S1) and after chemomechanical preparation using either NaOCl or CHX (S2), and after calcium hydroxide medication for 2-3 weeks (S3). 16S rRNA gene-based real-time qPCR was performed to detect and quantify total bacteria, Streptococcus species and Enterococcus faecalis.

Enrollment

49 patients

Sex

All

Ages

20 to 95 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

* Clinical diagnosis of apical periodontitis in a root-filled tooth assessed by radiography.

Exclusion criteria

* Presence of gross carious lesions in the diagnosed tooth, * Presence of fractures involving the periodontium of the diagnosed tooth, * Presence of periodontal pockets more than 4 mm deep in the diagnosed tooth, * Diagnosis of diabetes, * Diagnosis of HIV infection, * Other immunocompromising disease, * Antibiotic therapy within the previous 3 months.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

49 participants in 2 patient groups

1% sodium hypochlorite (NaOCl)
Active Comparator group
Description:
Retreatment of root-filled teeth with infection with 1% NaOCl as irrigation solution. Total bacterial counts, Streptococcal species and Enterococcus faecalis species were quantified using qPCR against 16SrRNA before irrigation (S1), after irrigation (S2), and after intracanal medication (S3).
Treatment:
Procedure: Retreatment of root-filled teeth with infection
2% chlorhexidine gluconate (CHX)
Active Comparator group
Description:
Retreatment of root-filled teeth with infection with 2% CHX as irrigation solution. Total bacterial counts, Streptococcal species and Enterococcus faecalis species were quantified using qPCR against 16SrRNA before irrigation (S1), after irrigation (S2), and after intracanal medication (S3).
Treatment:
Procedure: Retreatment of root-filled teeth with infection

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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