Antibiotic Exposure During Pregnancy Affects Infant Gut Microbiota

Peking University

Status: Enrolling

Conditions: Antibiotics Affecting Newborn Gut Microbiota

Treatments: Other: antibiotic treatment

Study type: Observational

Funder types: Other

Identifiers

NCT06479941

PKUPH-X2

Details and patient eligibility

About

Based on a prospective birth cohort, the investigators will collect biological samples from participants including pregnant women and newborns, to measure the gut microbial diversity and metabolites of newborns. These results systematically evaluate the effects of antibiotic exposure on the structure and function of gut microbiota. The project can reveal the effects of antibiotic exposure on the growth and development of gut microbiota in early life.

Enrollment: 450 estimated patients

Sex: All

Ages: 1 day to 12 months old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Pregnant woman

   • aged 20-40 years old
   • natural conception
   • single pregnancy
   • gestational age ≥36 weeks

2. Newborn

   • normal Apgar score
   • no serious congenital diseases

Exclusion criteria

Trial design

450 participants in 3 patient groups

Mother-infant cohort with antibiotic treatment group

Description:

E.g., Bacterial infection during pregnancy

Treatment:

Other: antibiotic treatment

Mother-infant cohort (Prophylactic antibiotics therapy)

Description:

E.g., cesarean section

Treatment:

Other: antibiotic treatment

Mother-infant cohort (Natural delivery)

Description:

E.g., Natural delivery

Treatment:

Other: antibiotic treatment