Antibiotic Exposure on Gut Microbiota and Motility Establishment in Newborns

Jilin University

Status: Active, not recruiting

Conditions: NEC - Necrotizing Enterocolitis

Study type: Observational

Funder types: Other

Identifiers

NCT06850896

25K041-001

Details and patient eligibility

About

This prospective cohort study aims to investigate the impact of early antibiotic exposure on the establishment of gut microbiota and motility in newborns, particularly preterm infants. The study will explore the correlation between antibiotic exposure, gut microbiota colonization, and 5-hydroxytryptamine (5-HT) levels, which are critical for gastrointestinal motility. The findings may provide insights into optimizing antibiotic use and improving gastrointestinal health in neonates.

Enrollment: 200 estimated patients

Sex: All

Ages: 24 to 36 weeks old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Newborns admitted within 72 hours of birth
• Gestational age 24-36 weeks (preterm) and term infants
• Informed consent obtained from parents or guardian

Exclusion criteria

• Congenital gastrointestinal malformations (e.g., intestinal atresia, Hirschsprung's disease)
• Severe systemic or organ-specific diseases
• Expected mortality due to severe illness

Trial design

200 participants in 1 patient group

Preterm Infants with Antibiotic Exposure

Description:

Description: Newborns with gestational age 24-36 weeks who receive antibiotics within the first 72 hours of life.