Antibiotic Prophylaxis for TEVAR

Zhejiang University

Status: Terminated

Conditions: Aortic Aneurysm, Thoracic; Aortic Dissection; Coarctation of Aorta; Aortic Diseases; Hematoma; Aorta

Treatments: Procedure: thoracic endovascular aortic repair

Study type: Observational

Funder types: Other

Identifiers

NCT05405790

IIT20220172A

Details and patient eligibility

About

The infection rate of thoracic endovascular aortic repair (TEVAR) is unknown due to a lack of epidemiological data. The rate currently available comes from researches conducted decades ago, when open surgery was the standard of care. Because of the potentially fatal consequences of a stent graft infection in the thoracic aorta, the investigators tend to prescribe antibiotic prophylaxis for at least three days. In this study, the investigators are going to collect data on patients receiving TEVAR in the past five years and provide the following information: a. the infection rate (MAGIC classification), b. the rate of fever, c. the results of the lab tests, such as the WBC count and C-reaction protein. d. risk factors associated with infection and fever.

Enrollment: 457 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Diagnosed with thoracic aortic diseases
2. Received TEVAR

Exclusion criteria

1. Suspected infectious aortic disease, such as a mycotic aneurysm.
2. TEVAR combined with open surgery
3. Antibiotics have been used more than 24 hours before the operation
4. Combined with immune deficiency disease or using hormone or immunosuppressant；
5. The treatment is for the complications of TEVAR, such as endoleak
6. Endovascular aortic repair for abdominal aortic disease
7. History of open aortic surgery or heart surgery.
8. Revascularization of visceral arteries during the TEVAR

Trial design

457 participants in 1 patient group

Patients receiving TEVAR

Treatment:

Procedure: thoracic endovascular aortic repair