Antibiotic Prophylaxis in Bariatric Surgery With Cefazolin: Concentration in Adipose Tissue

Universidade Federal de Pernambuco

Status and phase: Completed; Phase 4

Conditions: Obesity

Treatments: Drug: Cefazolin used in antimicrobial prophylaxis

Study type: Interventional

Funder types: Other

Identifiers

NCT01845363

Cefa01

Details and patient eligibility

About

Eighteen patients were given a dose of 2g Cefazolin in anesthetic induction, supplemented with 1g delivered through continuous infusion during surgery. Adipose samples, obtained at the beginning and end of surgery, were analyzed using high performance liquid chromatography.

Some published studies suggest that the dose of 2g does not supply the minimum inhibitory concentration for principal causal agents of surgical site infection.

To determine the concentration of Cefazolin in adipose tissue of patients undergoing bariatric surgery and to evaluate the relationship between concentrations obtained and body mass index (BMI).

Enrollment: 18 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• body mass index greater than 35 and less than 50kg/m2

Exclusion criteria

• Hypotension during surgery with use of vasoactive drugs
• renal disfunction (creatinine >1.5 mg/dL)

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Single Blind

---

18 participants in 1 patient group

Cefazolin

Other group

Description:

Cefazolin used in antimicrobial prophylaxis Cefazolin administered a first dose of 2g in anesthetic induction, followed by continuous dosage of 1g diluted in 250mL of saline solution for two hours. Two samples of subcutaneous tissue were collected for analysis: the first soon after the incision, and a second before skin synthesis. The samples were processed by High Pressure Liquid Chromatography (HPLC).

Treatment:

Drug: Cefazolin used in antimicrobial prophylaxis