Antibiotic Resistant Helicobacter Pylori in Rajavithi Hospital

Rajavithi Hospital

Status: Completed

Conditions: Dyspepsia

Treatments: Procedure: gastroscopic examination

Study type: Observational

Funder types: Other

Identifiers

NCT00285688

RH-CMR-002

Details and patient eligibility

About

Peptic ulcer disease is the most common gastrointestinal disease. Antibiotic resistant Helicobacter pylori is a major problem worldwide. The gold standard for Helicobacter pylori eradication is composed of Proton-pump inhibitor/Ranitidine bismuth citrate + Amoxycillin + Metronidazole /Clarithromycin. In Thailand, clarithromycin resistant strains increased and led to treatment failure. Data on file at Rajavithi Hospital showed that metronidazole resistant H. pylori was about 50% and Clarithromycin resistant strains accounted for 8%. This molecular genetic study will be performed in patients presenting with dyspepsia, who had an indication for gastroscopic examination, to explore the incidence of antibiotic resistant Helicobacter pylori in Rajavithi Hospital, Thailand.

Full description

Genetic and Biomolecular factors determining clarithromycin resistance will be characterized.

Enrollment: 200 estimated patients

Sex: All

Ages: 15+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• male or female with dyspepsia
• age > 15 years
• fulfil indication for gastroscopic examination
• able to give informed consent

Exclusion criteria

• contraindication for gastroscopic examination and biopsy

Trial design

200 participants in 2 patient groups

1

Description:

Gastroscope positive for H. pylori and resistant to clarithromycin

Treatment:

Procedure: gastroscopic examination

2

Description:

Gastroscope positive for H. pylori and not resistant to clarithromycin

Treatment:

Procedure: gastroscopic examination