Antibiotic Therapy of Acute Uncomplicated Colonic Diverticulitis

Uppsala University

Status: Completed

Conditions: Colonic Diverticulitis

Treatments: Drug: Antibiotic

Study type: Interventional

Funder types: Other

Identifiers

NCT01008488

AVOD-D33

Details and patient eligibility

About

The purpose of this study is to evaluate if antibiotic therapy is necessary for treatment of uncomplicated colonic diverticulitis.

The hypothesis is that Patients with acute uncomplicated colonic diverticulitis will recover the condition without antibiotic therapy and the lack of antibiotic therapy will not lead to complications.

The patients will be randomized to conservative treatment with and without antibiotic therapy.

Enrollment: 600 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adults with CT sign of acute colonic uncomplicated diverticulitis
• elevated CRP and LPK
• Temp.38c or more

Exclusion criteria

• patients with peritonitis, sepsis or CT- sign of complicated diverticulitis with abscesses or free abdominal air
• pregnancy
• immunological incompetence and immunosuppressive therapy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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600 participants in 2 patient groups

Antibiotic

Active Comparator group

Treatment:

Drug: Antibiotic

No antibiotic

No Intervention group