Antibiotic Treatment of Multiple Erythema Migrans

University Medical Centre Ljubljana

Status: Unknown

Conditions: Multiple Erythema Migrans

Treatments: Drug: doxycycline; Other: erythema migrans patients treated with doxycycline; Drug: ceftriaxone

Study type: Interventional

Funder types: Other

Identifiers

NCT01163994

MEM-0510

Details and patient eligibility

About

The purpose of this study is to compare the efficacy and safety of 15-day ceftriaxone versus 15-day doxycycline treatment in patients with multiple erythema migrans.

Enrollment: 500 estimated patients

Sex: All

Ages: 15+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• multiple erythema migrans in patients > 15 years

Exclusion criteria

• a history of Lyme borreliosis in the past
• pregnancy or lactation
• immunocompromised status
• serious adverse event to doxycycline or beta lactam antibiotic
• taking antibiotic with antiborrelial activity within 10 days

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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500 participants in 4 patient groups

MEM-ceftriaxone

Active Comparator group

Treatment:

Drug: ceftriaxone

MEM-doxycycline

Active Comparator group

Treatment:

Drug: doxycycline

controls

No Intervention group

EM-doxycycline

Active Comparator group

Treatment:

Other: erythema migrans patients treated with doxycycline