Antibiotics in Patients With Acute Respiratory Tract Infection With Procalcitonin as Parameter

Hannover Medical School (MHH)

Status and phase: Completed; Phase 2

Conditions: Respiratory Tract Infection

Treatments: Other: laboratory value procalcitonin

Study type: Interventional

Funder types: Other

Identifiers

NCT00688610

HannoverPro II

Details and patient eligibility

About

Antibiotics in patients with acute respiratory tract infections in primary care in consideration of procalcitonin as additive parameter.

The purpose of this study is to compare the ordinary manner of antibiotic- prescription with the prescription in consideration of procalcitonin-value in patients with acute respiratory tract infections.

Enrollment: 571 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 years or older
• Informed consent
• Respiratory tract infection based on the clinical judgement of the primary care physician

Exclusion criteria

• Antibiotic pretreatment in previous 14 days
• Portal hypertension
• Major surgeries or multiple trauma which require hospitalization, in previous 4 weeks
• Autoimmune disease and systemic diseases (lupus erythematodes, wegener´s disease)
• Peritoneal dialysis
• Acute treated or recently operated medullary c-cell-carcinoma, SCLC, carcinoid
• Other inflammatory diseases (e.g. urinary tract infection, pyelonephritis, pancreatitis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)