Antibody Detection in COVID-19 Cured Patients (SARS-CoV-2-CZ-Immunity) (SARSCoV2CZImun)

Institute of Health Information and Statistics of the Czech Republic

Status: Completed

Conditions: COVID; SARS-CoV-2

Treatments: Diagnostic Test: SARS-CoV-2 diagnostic rapid test; Diagnostic Test: Quantitative analysis of anti-SARS-CoV-2-antibodies

Study type: Observational

Funder types: Other

Identifiers

NCT04453280

UZIS 2020/2

Details and patient eligibility

About

The aim of the SARS-CoV-2-CZ-Immunity study is to determine the time profile of the presence of antibodies against SARS-CoV-2 in blood plasma by quantification of antibodies or performing a rapid test in COVID-19 cured patients.

Full description

COVID-19 is caused by a new type of coronavirus called SARS-CoV-2. It is a highly infectious disease, manifested mainly by fever, respiratory problems, muscle pain, and fatigue. However, despite the publication of hundreds of papers in the literature, fundamental information about the spread and course of the disease is still lacking in COVID-19. One of such key information is the time profile of the presence of antibodies against SARS-CoV-2 after the disease.

The SARS-CoV-2-CZ-Immunity study is aiming at the determination of the time profile of the presence of antibodies against SARS-CoV-2 in blood plasma by quantification of antibodies or performing a rapid test in COVID-19 cured patients.

Enrollment: 695 patients

Sex: All

Ages: 8+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• signed Informed Consent
• residing in Prague, Central Bohemian Region or South Moravian Region
• demographic criteria: persons aged 8-17 and persons aged 18 and more
• clinical criteria: (i) diagnosis of COVID-19 confirmed by PCR (ii) cured patients: clearance of SARS-CoV-2 viral RNA demonstrated by two consecutive negative RT-PCR results (iii) without acute health problems

Trial design

695 participants in 2 patient groups

Cohort 1 - Prague and Central Bohemian Region

Description:

A population cohort of cured patients based on epidemiologically defined demographic parameters - Prague and Central Bohemian Region population

Treatment:

Diagnostic Test: SARS-CoV-2 diagnostic rapid test

Diagnostic Test: Quantitative analysis of anti-SARS-CoV-2-antibodies

Cohort 2 - South Moravian Region

Description:

A population cohort of cured patients based on epidemiologically defined demographic parameters - South Moravian Region population.

Treatment:

Diagnostic Test: Quantitative analysis of anti-SARS-CoV-2-antibodies