Antibody Response in Hemodialysis and Non-dialysis Patients Diagnosed With COVID-19. (COV-HD)

Saint Petersburg State University, Russia

Status: Completed

Conditions: Dialysis; Covid19

Study type: Observational

Funder types: Other

Identifiers

NCT04633915

COVID

Details and patient eligibility

About

This is prospective cohort study aimed to compare antibody response against SARS-CoV-2 in dialysis patients and non-dialysis-dependent volunteers.

The research hypothesis is that dynamic of IgG antibodies against SARS-CoV-2 will differ in two groups.

To determine whether there is a statistically significant interaction between factors "group" and "time" on the titer of IgG antibodies against SARS-CoV-2, a two-way repeated measures ANOVA will be used.

Full description

In both groups level of IgG antibodies against SARS-CoV-2 will be measured at the Day 1 (10 weeks from the date of first symptoms), Weeks 8 and 16 from the Day 1.

Enrollment: 51 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18 years or older
• SARS-CoV-2 infection within 10 weeks prior enrollment, confirmed by PCR or strongly suspected on computed tomography
• Providing informed consent

Exclusion criteria

• Refusal to provide informed consent

Trial design

51 participants in 2 patient groups

Dialysis

Description:

Patients with CKD stage 5, treated with maintenance hemodialysis

Healthy

Description:

Volunteers who are not dialysis-dependent