Anticardiolipin Autoantibodies and Mortality in Septic Patients (aCLsepsis)

Military Hospital of Tunis

Status: Unknown

Conditions: Morality

Treatments: Biological: Blood samples

Study type: Observational

Funder types: Other

Identifiers

NCT04685278

Military Hospital of Tunis

Details and patient eligibility

About

The detection of antiphospholipid antibodies (aPL) is of interest because of their importance in the pathogenesis of arterial or venous thrombosis and their responsibility for a wide spectrum of clinical manifestations such as infection. The aim of the study was to assess the performance of antiphospholipid antibodies biomarker to predict in- hospital mortality in intensive care unit (ICU) septic patient's.

Full description

the investigators conducted a prospective single-center observational study including consecutive critically ill septic adults admitted to the intensive care unit. Clinical and laboratory data including chemiluminescence immunoassay for antiphospholipid antibodies [anticardiolipin (aCL), antiphosphatidylserine (aPS)] were obtained. Blood samples were collected on days 1, 3, 5, 8 and 10 of hospitalization. The primary study endpoint was ICU mortality defined as death before ICU discharge. Secondary end points included correlation between SOFA score and biological parameters.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients, admitted to the ICU for sepsis and older than 18 years

Exclusion criteria

• pregnancy
• clinical history of antiphospholipid syndrome
• auto-immune diseases
• immunosuppressive treatment