Anticholinergic Premedication Induced Fever in Pediatric Ambulatory Anesthesia With Ketamine

Inje University

Status: Completed

Conditions: Fever

Treatments: Drug: Glycopyrrolate

Study type: Interventional

Funder types: Other

Identifiers

NCT02430272

DSC-01-choe

Details and patient eligibility

About

Anticholinergic drugs have traditionally been used for their antisialagogue properties. But use of anticholinergic drugs can interfere with thermoregulation via inhibition of the parasympathetically mediated sweat secretion. Sweating inhibition can reduce heat elimination, and children's thermoregulation depend more on sweating than adults and they can become hyperthermic when given these agents.

The investigators evaluated the fever-causing effects of adjunctive anticholinergics in children under general anesthesia using ketamine.

Enrollment: 84 patients

Sex: All

Ages: 12 months to 8 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) Physical Status classification I
• underwent surgery between 8 to 9 am
• undergoing ambulatory anesthesia with ketamine

Exclusion criteria

• who required endotracheal intubation
• who were administered with medications other than ketamine

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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84 participants in 2 patient groups

Anticholinergic premedication

Experimental group

Description:

Premedication with 0.005mg/Kg of glycopyrrolate

Treatment:

Drug: Glycopyrrolate

Control group

No Intervention group

Description:

Same volume of normal saline