Antifungal Potential of Moringa Olifera Against Otomycosis

Deraya University

Status and phase: Completed; Early Phase 1

Conditions: Otomycosis

Treatments: Drug: Ear Drop; Drug: Moringa oleifera leaf 10mg/100ml

Study type: Interventional

Funder types: Other

Identifiers

NCT04768829

S85Motic

Details and patient eligibility

About

patients with Otomycosis were recognized by an ENT specialist. 20 patients were distributed randomly into two groups. The first group will be treated with Nystatin ear drops twice daily. The second group will be treated with Moringa ear drops. patients will be examined endoscopically by the ENT specialist. patient's swabs will be isolated and analyzed by ELISA.

Full description

Inclusion criteria:

(1) Otomycosis .

Exclusion criteria:

1. tympanic membrane perforation;
2. concurrent immune suppression,
3. and concurrent bacterial infection.

Enrollment: 10 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Otomycosis
2. ear inflammation

Exclusion criteria

1. tympanic membrane perforation
2. concurrent immune suppression,
3. concurrent bacterial infection.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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10 participants in 2 patient groups

Placebo group

Active Comparator group

Description:

Nystatin ear drops formulations prepared as intervention except for the addition of Moringa prepared using biodegradable polymers in aseptic condition and tested for sensitivity

Treatment:

Drug: Ear Drop

Moringa group

Experimental group

Description:

Moringa ear drops prepared using biodegradable polymers in aseptic condition and tested for sensitivity

Treatment:

Drug: Moringa oleifera leaf 10mg/100ml