Antihistamines, Amantadine and Evolution of the SARS-CoV-2 Infection

Consorci Sanitari de Terrassa

Status: Enrolling

Conditions: COVID-19

Treatments: Drug: Antihistamine; Drug: Amantadine

Study type: Observational

Funder types: Other

Identifiers

NCT05504057

02-22-161-060

Details and patient eligibility

About

The rates of symptomatic COVID19 infection, hospital admission among COVID19 cases and survival would be quantified in patiens chronically treated with antihistamines or amantadine, with the aim of determining the role of antihistamines and amantadine in the evolution of COVID19.

Full description

BACKGROUND: According to previous reports, all 84 eldery residents in nuersing homes in Yespes (Toledo, Spain), had a 100% of positive serology for COVID-19 in June 2020, but none died nor hospitalized after receiving early treatment with antihistamines. Other case reports have suggested a protective role of amantadine, since infected patients showed a very mild COVID19 infection.

OBJECTIVES.Determine the role of antihistamines and amantadine in the evolution of COVID19.

METHODS. Describe the rate of hospitalization, ICU, survival, postcovid syndrome and thrombosis among COVID 19 cases having antihistamines and amantadine as chronic treatments.

The rates would be stratified by age groups and compared with the same age groups of the population assigned to the public free Access Terrassa Health Consortium.

Enrollment: 140,660 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: Patients having chronic treatment with antihistamines or amantadine -

Exclusion Criteria: None

Trial design

140,660 participants in 2 patient groups

Patients with chronic treatment with antihistamines or amantadine

Description:

The % of patients having antihistamines or amantadine as chronic treatment that suffered COVID would be compared to the population of the Terrassa Health Consortium (THC) of the same age groups.

Treatment:

Drug: Amantadine

Drug: Antihistamine

Other population of the THC

Description:

The % of patients of the Terrassa Health Consortium that suffered COVID19 infection of the same age groups.