Antihypertensive Effect of Simvastatin in Hypertensive Patients

Hospital de Clinicas de Porto Alegre

Status and phase

Unknown

Phase 4

Conditions

Hypertension

Treatments

Drug: Simvastatin 40mg

Drug: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT00704548

08014

Details and patient eligibility

About

Few trials have investigated the hypotensive effect of the Statins. Most were not specifically aimed at this pleiotropic effect or had methodological problems. The possible hypotensive effect may explain part of the favorable results of the Statins use on cardiovascular prevention independently from its action on the cholesterol profile.

The purpose of this study is to determine the effect of Simvastatin on the blood pressure

Full description

This is a randomized double blind parallel clinical trial where hypertensive patients with controlled or uncontrolled blood pressure and without evidence of target-organ damage will be selected. Subjects will receive Simvastatin 40 mg once daily or placebo and a baseline and eight weeks ABPM will performed. The main outcome will be the difference in systolic BP in the 24h-ABPM.

Enrollment

92 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Hypertensive patients with controlled or uncontrolled blood pressure

Exclusion criteria

Secondary causes of hypertension;
Systolic Blood pressure >= 180 mmHg and/or diastolic blood pressure >= 110 mmHg
Complain of side effects related to Statins
Diabetes
Established target-organ damage (myocardial infarction, stroke, angina, heart failure, peripheral vascular disease)
Renal disease (creatinine > 1,5 mgdl).