Antimicrobial Photodynamic Therapy Associated With the Conventional Endodontic Treatment: A Clinical and Microbiological Study

Universidade Federal Fluminense

Status: Completed

Conditions: Polymerase Chain Reaction; Infection; Enterococcal Infections; Candida; Dental Pulp Necrosis; Photochemotherapy Reaction

Treatments: Procedure: Conventional endodontic treatment; Radiation: ANTIMICROBIAL PHOTODYNAMIC THERAPY

Study type: Interventional

Funder types: Other

Identifiers

NCT03212729

aPDT and microorganisms

Details and patient eligibility

About

Microorganisms play a critical role in the etiology and pathogenesis of apical periodontitis. Enterococcus faecalis and Candida sp. are frequently associated with persistent infections. The aim of this study was evaluated the antimicrobial photodynamic therapy (aPDT) as an adjunct of the endodontic treatment. Ten uniradicular teeth [control group (CG)=4 and test group (TG)=6] with primary endodontic infections were analyzed. Microbiological samples were collected before and after the chemical-mechanical instrumentation (CMI), after the aPDT (for the TG) and after the temporary restorations removal (second session).

Enrollment: 10 patients

Sex: All

Ages: 17 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with teeth with: single canal with endodontic infection, intact pulp chamber walls, necrotic pulp confirmed by sensitivity pulp tests, and clinical and radiographic evidence of asymptomatic apical periodontitis

Exclusion criteria

• Patients with teeth with: gross carious lesions, root or crown fracture, previous endodontic treatment, gingival recession and periodontal pockets deeper than 4 mm.
• Patients pregnant, lactating, with systemic diseases that could compromise the immune system, individuals who received antibiotic therapy within the previous 3 months or in immunosuppressive treatment.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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10 participants in 2 patient groups

Control Group

Active Comparator group

Description:

CONVENTIONAL ENDODONTIC TREATMENT

Treatment:

Procedure: Conventional endodontic treatment

Test Group

Experimental group

Description:

CONVENTIONAL ENDODONTIC TREATMENT ASSOCIATED WITH ANTIMICROBIAL PHOTODYNAMIC THERAPY

Treatment:

Procedure: Conventional endodontic treatment

Radiation: ANTIMICROBIAL PHOTODYNAMIC THERAPY