Antimicrobial Photodynamic Therapy in Treatment of Aggressive Periodontitis (Stage III, Grade C Periodontitis)

University of Ljubljana

Status: Completed

Conditions: Aggressive Periodontitis

Treatments: Device: antimicrobial photodynamic therapy; Drug: systemic antibiotics

Study type: Interventional

Funder types: Other

Identifiers

NCT05655338

PHOTODYNAMICTHERAPY

Details and patient eligibility

About

Treatment of aggressive periodontitis (stage III, grade C periodontitis) represents a big challenge. The aim of the study was to compare the long-term results of antimicrobial photodynamic therapy (aPDT) and antibiotic therapy as an adjunct to conventional non-surgical therapy in patients with aggressive periodontitis. Clinical parameters of probing depth, clinical attachment level and bleeding on probing (BOP) were assessed at baseline, 3, 6, 9 and 12 months after treatment.

Full description

Background: Treatment of aggressive periodontitis (stage III, grade C periodontitis) represents a big challenge. The aim of the study was to compare the long-term results of antimicrobial photodynamic therapy (aPDT) and antibiotic therapy as an adjunct to conventional non-surgical therapy in patients with aggressive periodontitis. Materials and methods: Twenty subjects with untreated aggressive periodontitis (stage III, grade C periodontitis) were divided into two groups: the test group (TG) received non-surgical therapy and two sessions of aPDT using a laser (HELBO TheraLite laser) with a wavelength of 670nm associated with HELBO Blue photosensitizer, and the control group (CG) received non-surgical therapy and antibiotics (amoxicillin 500mg and metronidazole 400mg, 7 days). Clinical parameters of probing depth, clinical attachment level and bleeding on probing (BOP) were assessed at baseline, 3, 6, 9 and 12 months after treatment.

Enrollment: 20 patients

Sex: All

Ages: 18 to 38 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• aggressive periodontitis (stage III, grade C periodontitis)
• nonsmokers
• at least 20 teeth in oral cavity
• systemically healthy

Exclusion criteria

• any previous periodontal treatment
• smoking
• pregnancy
• ingestion of systemic antibiotics within three months before therapy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

ANTIMICROBIAL PHOTODYNAMIC THERAPY

Experimental group

Description:

The patients received antimicrobial photodynamic therapy after non-surgical periodontal treatment

Treatment:

Device: antimicrobial photodynamic therapy

SYSTEMIC ANTIBIOTICS

Experimental group

Description:

The patients received systemic antibiotics after non-surgical periodontal treatment

Treatment:

Drug: systemic antibiotics